PreBiomics Beta Program
PreBiomics Beta Program
Project completed
Over fifty Italian dental clinics participated in the research project promoted by PreBiomics between 2020 and 2022, contributing to the creation of the largest database of human oral microbiomes currently available. The enthusiasm, dedication, and passion of the PreBiomics Beta Testers have provided an essential drive enabling the development of a revolutionary and personalized approach to the prevention and treatment of peri-implant diseases.
| A.P.G.R. – Roma Dott. Giovanni Di Caccamo Dott. Riccardo Caracci |
Studio Dentistico Associato Gobbato – Padova Dott. Luca Gobbato Dott. Simonetta Marchesan |
| Bressan Associati Studio Dentistico – Pordenone Prof. Eriberto BressanDott. Riccardo Martarello |
Studio Dentistico Associato Paniz – Padova Dott. Gianluca Paniz Dott.ssa Sofia Drivas Dott.ssa Anna Zorzo Dott.ssa Carola Bordin Dott.ssa Cristina Preghel |
| Centro Dentale Francesca Manfrini – Trento Dott.ssa Francesca Manfrini |
Studio Dentistico Barcelli – Trento Dott. Nicola BarcelliDott. Federico Folchini |
| Centro Medico Odontoiatrico Torrisi – Catania Dott. Paolo Torrisi |
Studio Dentistico Candiago – Pordenone Dott. Jacopo Candiago Dott.ssa Teresa Gutiérrez |
| Centro Odontoiatrico Dott. Oreglia – Verona Dott. Francesco Oreglia Dott.ssa Silvia Tomassini Dott.ssa Claudia Ocera Dott.ssa Denisa Matei |
Studio Dentistico Donati – Perugia Dott. Mauro Donati |
| Centro Odontoiatrico Sforza – Bologna Dott. Nicola Marco Sforza Dott.ssa Mascia Ronconi Dott. Leoluca Valeriani Dott.ssa Anna Franchini |
Studio Dentistico Dott. Cardaropoli – Torino Dott. Daniele Cardaropoli |
| Centro Odontoiatrico Tommaseo – Trieste Dott. Massimo Sossi Dott.ssa Elisa Sossi Dott.ssa Ilaria de VisintiniDott. Gianni de VisintiniDott.ssa Mirta Cozzolino Dott.ssa Elisa Ritossa |
Studio dentistico dr Thomas Zorzi odontoiatra – Trento Dott. Thomas Zorzi Dott.ssa Nicoletta Corradini |
| Dott.ssa Martina Stefanini – Bologna Dott.ssa Martina Stefanini Dott.ssa Alice Riccardi Dott.ssa Mariam Ben Mahdhi |
Studio Dentistico Fumarola Dott. Martino – Trento Dott. Martino Fumarola |
| in-4 Studio dentistico associato – Verona Dott. Luca Landi Dott.ssa Francesca Rizzi Dott.ssa Sara Fontana Dott.ssa Caterina Pagliari |
Studio Dentistico Guazzo – Vicenza Dott. Riccardo Guazzo |
| Maia Dentis – Bolzano Dott. Antonio Bonaccorso Dott.ssa Daniela Vicentini |
Studio dentistico Ometto – Treviso Dott. Lucio Ometto Dott.ssa Annachiara Trevisan |
| Microdental di Dott. Giovanni Sammarco – Trento Dott. Giovanni Sammarco Dott.ssa Silvia Bortolotti |
Studio Dentistico Pulcini – Ascoli Piceno Dott. Alberto Pulcini |
| Oberholtzer & Martini – Vicenza Dott. Davide Oberholtzer Dott.ssa Alessia Colella Dott.ssa Silvia Schiro |
Studio Dentistico Sbricoli Dott. Luca – Padova Dott. Luca Sbricoli Dott.ssa Silvia Bobbo Dott. Davide Scettri Dott.ssa Benedetta Costa |
| Orizzonte Dentale – Torino Dott. Ivan Zanini Dott. Marco BuninoDott.ssa Simona Grosso |
Studio di Odontoiatria Ricostruttiva – Roma Dott. Luca Landi Dott.ssa Chiara Cappetta |
| PerioDental Studio di Fabrizi Dott. Simone – Frosinone Dott. Fabrizi Simone Dr.ssa Gemmiti Roberta |
Studio Gatti – Milano Dott. Claudio Gatti Dott. Fulvio Gatti |
| Poliambulatorio Gualini – Bergamo Dott. Giacomo Gualini |
Studio Giammarini – Fermo Dott. Andrea Giammarini |
| Recchia Ambulatorio Polispecialistico- Verona Dott.ssa Paola Chiaramonte Dott. Giorgio Stroppa |
Studio medico odontoiatrico Pellitteri Dott. Pellitteri – Bolzano Dott. Giuseppe Pellitteri |
| Studio Associato Odontoiatrico Tomasi Bottamedi Varotto – Trento Dott. Cristiano Tomasi Dott.ssa Sabrina BottamediDott.ssa Federica Medini |
Studio Odontoiatrico Associato Albertini Bertelle Conci – Trento Dott. Alberto Bertelle |
| Studio Carlo Ghezzi – Milano Dott. Carlo Ghezzi |
Studio Odontoiatrico dott. Tiziano Bombardelli – Trento Dott. Tiziano Bombardelli Dott.ssa Maria Oros Dott.ssa Romina Waldner |
| Studio Cavalcanti & Venezia – Bari Dott. Raffaele Cavalcanti Dott. Vittorio Blardi Dott.ssa Antonella Degennaro Dott.ssa Raisa Rosioara |
Studio Odontoiatrico Dott.ssa Silvia Masiero – Varese Dott.ssa Silvia Anna Masiero Dott. Simone Roatti Dott.ssa Silvia Musella |
| Studio Cenzi – Vicenza Dott. Alvise Cenzi Venezze |
Studio Odontoiatrico Dr. Donati Roberto – Trento Dott. Roberto Donati Dott.ssa Beatrice Marchiori Elena Sertinean |
| Studio Dentistico Associato – Dr. Broseghini M. e Dr. Dell’Acqua – Trento Dott. Federico Dell’Acqua Dott.ssa Serena Dell’Acqua Dott.ssa Giulia Dalmut Dott.ssa Karin Covi Dott. Betim Djaferi Dott.ssa Katarina Minarski |
Studio Odontoiatrico Guerino Paolantoni – Napoli Dott. Guerino Paolantoni Dott.ssa Chiara Galano Dott.ssa Elena Andolfi |
| Studio Dentistico Associato Dott. Tomasi – Ghensi – Varotto – Trento Dott. Paolo Ghensi Dott.ssa Daniela Vicentini |
Studio odontoiatrico Piacentini – Pavia Dott. Giacomo Piacentini Dott. Gianluca Spinoglio |
EIC Transition - PreBiomicsPMT
EIC Transition - PreBiomicsPMT™
Ongoing project
In the context of the PreBiomicsPMT™ project we will enable treatment recommendations for each patient based on the bacterial composition of their plaque microbiome.
Every year, around 20 million dental implant procedures are performed worldwide. The market for dental implants was worth €3.6 billion in 2020 and is growing at a rate of 11% each year.
Unfortunately, there is a risk of dental implant-related diseases due to microorganisms and biofilm formation. These diseases can harm both oral and overall health. More than 50% of patients with dental implants develop a condition called mucositis, which is an inflammation of the soft tissues surrounding the implant. If left untreated, mucositis can progress to peri-implantitis, a severe infection that affects both the soft and hard tissues, potentially leading to implant failure. Currently, there are no reliable tools to assess the severity of these diseases or predict their progression. To date, dentists can only provide general treatments without knowing the specific composition of the plaque microbiome triggering and sustaining the disease.
At PreBiomics, we have developed a precision-medicine test that analyzes the microbial composition of the plaque biofilm collected around dental implants. Over the course of 10 years of research, we have discovered that the presence of specific bacteria is crucial in predicting the severity and progression of infections. Our test, called PreBiomicsPMT™, utilizes metagenomics and an AI algorithm to analyze the bacterial composition of the plaque microbiome. This allows us to monitor and diagnose the disease and provide personalized treatment recommendations for each patient based on their specific bacterial profile.
Building upon the successful results of our previous ERC Proof of Concept projects, this EIC-Transition project aims to automate the testing process using robotics. This will help reduce costs and speed up the delivery of results. We will also create a comprehensive database that will be used to develop an antibiotic resistance panel and enhance our decision support system (DSS) for dentists. Additionally, we will conduct a validation study to demonstrate the effectiveness of our DSS in predicting disease and treatment outcomes.
In parallel with the technical advancements, we will develop an intellectual property rights (IPR) management plan to protect our research findings. We will extensively study the dental implants market and understand the needs and expectations of our customers and investors. This knowledge will contribute to the development of a robust business plan for effectively marketing and exploiting our product.
Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them. Grant Agreement n° 101113004.
ERC Proof of Concept - PB3P
ERC Proof of Concept - PB3P
Project completed
Combining the results from the PreBiomics Beta Program, the PB3P project leveraged high-throughput metagenomics to explore the microbial diversity within the oral samples.
In the PB3P project, we isolated 100 bacterial colonies associated with Fusobacterium nucleatum, a key player in the development of peri-implant diseases. We managed to identify clear microbial signatures of healthy, mucositis and peri-implantitis implants, with the latest mainly composed of PiRC™ species and new uncharacterized ones. Using the reconstructed and isolated genomes, we further expanded the F. nucleatum phylogenetic tree composed of 5 different subspecies of which we characterized the antibiotic profiles and the presence of virulence factors.